Clinical efficacy of domino liver transplantation: An analysis of two cases

Abstract

Objective To investigate the clinical efficacy of domino liver transplantation (DLT) and to provide a refe-rence for expanding the sources of donor livers. Methods The clinical data of two cases who underwent DLT at our hospital in 2021 were collected, and a literature review was performed. Results Donor 1 was a healthy subject, recipient 1 (DLT donor) was a patient with ornithine transcarbamylase deficiency, and recipient 2 (DLT recipient) was a patient with Cirgler-Najiar syndrome. Donor 2 was a brain-dead donor as per the internationally standardized definitions, recipient 3 (DLT donor) was a patient with familial hypercholesterolemia, and recipient 4 (DLT recipient) was a patient with malignant liver tumor. After transplantation, all patients experienced recovery of their liver function in 1 week, and were discharged from the hospital after 2 to 4 weeks of hospitalization. Recipient 2 developed thrombosis in the left portal vein on day 4 after operation; after emergent thrombolysis and anticoagulant therapy, the blood flow of the portal vein was effectively improved, and no serious outcomes were identified; the bilirubin level of the patient returned to normal at 1 week after operation. Recipient 4 developed hyperlipidemia after operation and was treated with atorvastatin and ezetimibe for lipid regulation; the patient was followed up till now with no additional complications found. Conclusion DLT can effectively expand the sources of donor livers.

Keywords

• liver transplantation|transplant recipients|living donors|treatment outcome|case reports