Nature and Science of Sleep (Mar 2022)
The Association Between Insomnia and Atherosclerosis: A Brief Report
Abstract
Xian-Li Pan,1 Li Nie,1 Shu-Yi Zhao,1 Xiao-Bao Zhang,2 Shan Zhang,2 Zeng-Feng Su2 1Chaohu Hospital Affiliated with Anhui Medical University, Chaohu City, People’s Republic of China; 2Department of General Medicine, Chaohu Hospital Affiliated with Anhui Medical University, Chaohu City, People’s Republic of ChinaCorrespondence: Zeng-Feng Su, Tel +86 0551-82321572, Email [email protected]: The objective of the study was to clarify the occurrence of atherosclerosis in patients with insomnia.Methods: A total of 60 patients with insomnia and 58 patients in a control group were selected to measure blood glucose, blood lipids and other biochemical and physiological indicators. Brachial-ankle pulse wave velocity (baPWV) was measured to assess arterial stiffness, and color Doppler ultrasound was used to examine carotid artery intima-media thickness (CIMT) and plaque incidence. These indicators were used to determine the occurrence and degree of carotid atherosclerosis, and to compare the differences between the two groups.Results: While there was no significant difference in biochemical or physiological indicators between the two groups (P > 0.05), the baPWV, CIMT, and incidence of carotid plaque in the insomnia group were higher than the control group. In addition, the baPWV, CIMT, and incidence of carotid plaque in the chronic insomnia group were higher than that in the short-term insomnia group. Multiple linear regression analysis was carried out to analyze the effects of insomnia, systolic blood pressure, blood glucose, triglycerides, cholesterol, BMI, age and low-density lipoprotein on atherosclerosis. The results showed that increased CIMT was significantly correlated with insomnia in atherosclerosis group (R2=0.27 on the left, R2=0.37 on the right, P < 0.001).Conclusion: Insomnia correlated with increased arterial stiffness and carotid atherosclerosis, and as the duration of insomnia prolongs, the correlation between them became more obvious.Keywords: insomnia, brachial-ankle pulse wave velocity, carotid intima-media thickness, carotid plaque
