Nature Communications (Nov 2021)
Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
- Maximilian W. Schenk,
- Sam Humphrey,
- A. S. Md Mukarram Hossain,
- Mitchell Revill,
- Sarah Pearsall,
- Alice Lallo,
- Stewart Brown,
- Samuel Bratt,
- Melanie Galvin,
- Tine Descamps,
- Cong Zhou,
- Simon P. Pearce,
- Lynsey Priest,
- Michelle Greenhalgh,
- Anshuman Chaturvedi,
- Alastair Kerr,
- Fiona Blackhall,
- Caroline Dive,
- Kristopher K. Frese
Affiliations
- Maximilian W. Schenk
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Sam Humphrey
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- A. S. Md Mukarram Hossain
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Mitchell Revill
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Sarah Pearsall
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Alice Lallo
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Stewart Brown
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Samuel Bratt
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Melanie Galvin
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Tine Descamps
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Cong Zhou
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Simon P. Pearce
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Lynsey Priest
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Michelle Greenhalgh
- Christie National Health Service Foundation Trust, Division of Cancer Sciences, The University of Manchester
- Anshuman Chaturvedi
- Christie National Health Service Foundation Trust, Division of Cancer Sciences, The University of Manchester
- Alastair Kerr
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Fiona Blackhall
- Christie National Health Service Foundation Trust, Division of Cancer Sciences, The University of Manchester
- Caroline Dive
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- Kristopher K. Frese
- Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
- DOI
- https://doi.org/10.1038/s41467-021-26823-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX) models reveal a mechanism of drug resistance in SCLC mediated by Notch and nitric oxide activation of soluble guanylate cyclase signalling.
