Nature Communications (Nov 2018)
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
- Egil Ferkingstad,
- Asmundur Oddsson,
- Solveig Gretarsdottir,
- Stefania Benonisdottir,
- Gudmar Thorleifsson,
- Aimee M. Deaton,
- Stefan Jonsson,
- Olafur A. Stefansson,
- Gudmundur L. Norddahl,
- Florian Zink,
- Gudny A. Arnadottir,
- Bjarni Gunnarsson,
- Gisli H. Halldorsson,
- Anna Helgadottir,
- Brynjar O. Jensson,
- Ragnar P. Kristjansson,
- Gardar Sveinbjornsson,
- David A. Sverrisson,
- Gisli Masson,
- Isleifur Olafsson,
- Gudmundur I. Eyjolfsson,
- Olof Sigurdardottir,
- Hilma Holm,
- Ingileif Jonsdottir,
- Sigurdur Olafsson,
- Thora Steingrimsdottir,
- Thorunn Rafnar,
- Einar S. Bjornsson,
- Unnur Thorsteinsdottir,
- Daniel F. Gudbjartsson,
- Patrick Sulem,
- Kari Stefansson
Affiliations
- Egil Ferkingstad
- deCODE Genetics/Amgen, Inc.
- Asmundur Oddsson
- deCODE Genetics/Amgen, Inc.
- Solveig Gretarsdottir
- deCODE Genetics/Amgen, Inc.
- Stefania Benonisdottir
- deCODE Genetics/Amgen, Inc.
- Gudmar Thorleifsson
- deCODE Genetics/Amgen, Inc.
- Aimee M. Deaton
- deCODE Genetics/Amgen, Inc.
- Stefan Jonsson
- deCODE Genetics/Amgen, Inc.
- Olafur A. Stefansson
- deCODE Genetics/Amgen, Inc.
- Gudmundur L. Norddahl
- deCODE Genetics/Amgen, Inc.
- Florian Zink
- deCODE Genetics/Amgen, Inc.
- Gudny A. Arnadottir
- deCODE Genetics/Amgen, Inc.
- Bjarni Gunnarsson
- deCODE Genetics/Amgen, Inc.
- Gisli H. Halldorsson
- deCODE Genetics/Amgen, Inc.
- Anna Helgadottir
- deCODE Genetics/Amgen, Inc.
- Brynjar O. Jensson
- deCODE Genetics/Amgen, Inc.
- Ragnar P. Kristjansson
- deCODE Genetics/Amgen, Inc.
- Gardar Sveinbjornsson
- deCODE Genetics/Amgen, Inc.
- David A. Sverrisson
- deCODE Genetics/Amgen, Inc.
- Gisli Masson
- deCODE Genetics/Amgen, Inc.
- Isleifur Olafsson
- Department of Clinical Biochemistry, Landspítali University Hospital
- Gudmundur I. Eyjolfsson
- Laboratory in Mjódd (RAM)
- Olof Sigurdardottir
- Department of Clinical Biochemistry, Akureyri Hospital
- Hilma Holm
- deCODE Genetics/Amgen, Inc.
- Ingileif Jonsdottir
- deCODE Genetics/Amgen, Inc.
- Sigurdur Olafsson
- Department of Internal Medicine, Landspitali University Hospital
- Thora Steingrimsdottir
- Faculty of Medicine, University of Iceland
- Thorunn Rafnar
- deCODE Genetics/Amgen, Inc.
- Einar S. Bjornsson
- Faculty of Medicine, University of Iceland
- Unnur Thorsteinsdottir
- deCODE Genetics/Amgen, Inc.
- Daniel F. Gudbjartsson
- deCODE Genetics/Amgen, Inc.
- Patrick Sulem
- deCODE Genetics/Amgen, Inc.
- Kari Stefansson
- deCODE Genetics/Amgen, Inc.
- DOI
- https://doi.org/10.1038/s41467-018-07460-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Genome-wide association studies have so far identified eight risk loci for gallstone disease. Here, the authors perform meta-analysis in cohorts from Iceland and the UK which reveals further 21 common and low-frequency risk variants that highlight the role of bile acid homeostasis in gallstone disease.
