Molecular & Cellular Oncology (Mar 2021)

Trex2 responds to damaged replication forks in diverse ways

  • Paul Hasty

DOI
https://doi.org/10.1080/23723556.2021.1881394
Journal volume & issue
Vol. 8, no. 2

Abstract

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Three prime Repair Exonuclease 2 (Trex2) alters replication fork (RF) stability and mutation levels in cells defective for homologous recombination (HR). Trex2 has multiple functions that can either cause or supress RF instability in cells with different HR-defects. Why does Trex2 have such diverse effects on RF maintenance?