Nature Communications (Nov 2017)

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

  • Nadine Ait-Bouziad,
  • Guohua Lv,
  • Anne-Laure Mahul-Mellier,
  • Shifeng Xiao,
  • Gizem Zorludemir,
  • David Eliezer,
  • Thomas Walz,
  • Hilal A. Lashuel

DOI
https://doi.org/10.1038/s41467-017-01575-4
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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The Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligomeric protein/phospholipid complexes.