449 Polygenic risk scores for liver injury are associated with the risk for autoimmune hepatitis in patients treated with atezolizumab

• David Roe,
• Ira Mellman,
• Mark McCarthy,
• Ashis Saha,
• Rajat Mohindra,
• Christian Hammer,
• Cameron Adams,
• G Scott Chandler

Affiliations

David Roe

Department of Emergency Medicine, Whiston Hospital, Warrington Road, Prescot, Merseyside L35 5DR, UK

Ira Mellman

Genentech, Inc., South San Francisco, CA, USA

Mark McCarthy

1 Department of Clinical Education, University Hospitals of Leicester NHS Trust, Leicester, UK

Ashis Saha

1Genentech, South San Francisco, CA, USA

Rajat Mohindra

7F.Hoffmann-La Roche Ltd, Basel, Switzerland

Christian Hammer

1Genentech, South San Francisco, CA, United States

Cameron Adams

Genetic Epidemiology and Genomics Laboratory, Divisions of Epidemiology and Biostatistics, School of Public Health, University of California Berkeley, Berkeley, California, USA

G Scott Chandler

6Genentech/Roche, Basel, Switzerland