Nature Communications (Nov 2017)

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

  • Gabriela E. Davey,
  • Zenita Adhireksan,
  • Zhujun Ma,
  • Tina Riedel,
  • Deepti Sharma,
  • Sivaraman Padavattan,
  • Daniela Rhodes,
  • Alexander Ludwig,
  • Sara Sandin,
  • Benjamin S. Murray,
  • Paul J. Dyson,
  • Curt A. Davey

DOI
https://doi.org/10.1038/s41467-017-01680-4
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

Histone H2A–H2B dimers in nucleosomes contain an acidic patch, a highly electronegative cleft. Here, the authors characterize a family of binuclear ruthenium compounds that selectively target the acidic patch, generating intra-nucleosomal H2A-H2B cross-links as well as inter-nucleosomal cross-links.