Frontiers in Cellular and Infection Microbiology (Nov 2022)
Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?
- Zihan Liang,
- Zihan Liang,
- Zihan Liang,
- Yiyao Wang,
- Yiyao Wang,
- Yiyao Wang,
- Yixiang Lai,
- Yixiang Lai,
- Yixiang Lai,
- Jingyi Zhang,
- Jingyi Zhang,
- Jingyi Zhang,
- Lanlan Yin,
- Lanlan Yin,
- Lanlan Yin,
- Xiang Yu,
- Xiang Yu,
- Xiang Yu,
- Yongqin Zhou,
- Yongqin Zhou,
- Yongqin Zhou,
- Xinzhi Li,
- Xinzhi Li,
- Yinhong Song,
- Yinhong Song,
- Yinhong Song
Affiliations
- Zihan Liang
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China
- Zihan Liang
- Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
- Zihan Liang
- College of Basic Medical Science, China Three Gorges University, Yichang, China
- Yiyao Wang
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China
- Yiyao Wang
- Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
- Yiyao Wang
- College of Basic Medical Science, China Three Gorges University, Yichang, China
- Yixiang Lai
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China
- Yixiang Lai
- Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
- Yixiang Lai
- College of Basic Medical Science, China Three Gorges University, Yichang, China
- Jingyi Zhang
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China
- Jingyi Zhang
- Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
- Jingyi Zhang
- College of Basic Medical Science, China Three Gorges University, Yichang, China
- Lanlan Yin
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China
- Lanlan Yin
- Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
- Lanlan Yin
- College of Basic Medical Science, China Three Gorges University, Yichang, China
- Xiang Yu
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China
- Xiang Yu
- Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
- Xiang Yu
- College of Basic Medical Science, China Three Gorges University, Yichang, China
- Yongqin Zhou
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China
- Yongqin Zhou
- Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
- Yongqin Zhou
- College of Basic Medical Science, China Three Gorges University, Yichang, China
- Xinzhi Li
- College of Basic Medical Science, China Three Gorges University, Yichang, China
- Xinzhi Li
- Affiliated Renhe Hospital of China Three Gorges University, Yichang, China
- Yinhong Song
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China
- Yinhong Song
- Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
- Yinhong Song
- College of Basic Medical Science, China Three Gorges University, Yichang, China
- DOI
- https://doi.org/10.3389/fcimb.2022.1050396
- Journal volume & issue
-
Vol. 12
Abstract
Klebsiella pneumoniae (K. pneumoniae) is a typical gram-negative iatrogenic bacterium that often causes bacteremia, pneumonia and urinary tract infection particularly among those with low immunity. Although antibiotics is the cornerstone of anti-infections, the clinical efficacy of β-lactamase and carbapenems drugs has been weakened due to the emergence of drug-resistant K. pneumoniae. Recent studies have demonstrated that host defense plays a critical role in killing K. pneumoniae. Here, we summarize our current understanding of host immunity mechanisms against K. pneumoniae, including mechanical barrier, innate immune cells, cellular immunity and humoral immunity, providing a theoretical basis and the new strategy for the clinical treatment of K. pneumoniae through improving host immunity.
Keywords
