Nature Communications (Feb 2016)

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

  • Andrew T. McGuire,
  • Matthew D. Gray,
  • Pia Dosenovic,
  • Alexander D. Gitlin,
  • Natalia T. Freund,
  • John Petersen,
  • Colin Correnti,
  • William Johnsen,
  • Robert Kegel,
  • Andrew B. Stuart,
  • Jolene Glenn,
  • Michael S. Seaman,
  • William R. Schief,
  • Roland K. Strong,
  • Michel C. Nussenzweig,
  • Leonidas Stamatatos

DOI
https://doi.org/10.1038/ncomms10618
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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The induction of broadly neutralizing antibodies (bNAbs) is a goal of HIV-1 vaccine research. Here the authors demonstrate the ability of an HIV Env-derived immunogen to bind germline precursors of a class of bNAbs and to activate the corresponding B cells in a knock-in mouse model