Фармакокинетика и Фармакодинамика (Sep 2016)
Experimental study of chronic toxicity and anti-inflammatory properties of the drug Dilept
Abstract
The purpose of this study is to evaluate the chronic toxicity of the drug dilept upon a daily orally administration for 6 months at doses of 16 and 160 mg/kg. Detailed clinical and laboratory examinations did not reveal any chronic toxic effect in animals except for reversible dystrophic changes in heart, kidneys, liver, reversible high level of creatinine in urine and degenerative forms of red blood cells in rats treated with drug at dose 160 mg/kg. Evaluation of anti-inflammatory properties of dilept in the inflammatory reaction induced by concanavalin A showed that at doses of 0,1 and 10 mg/kg i.p. in mice led to a significant suppression of the inflammatory response. Study showed that dilept has no allergenic properties.
