THE PARAMETERS OF THE HEMOSTATIC SYSTEM, GENE POLYMORPHISMS IN CHILDREN WITH THROMBOTIC EVENTS IN THE PEDIATRIC CLINIC OF NOVOSIBIRSK STATE REGIONAL CLINICAL HOSPITAL

Abstract

The aim of the research was to study the effect of genetic predictors of thrombotic/ischemic events in children with the developed complications and born mature or premature. Material and methods. A prospective follow-up monitoring of 47 patients (inpatients of the State Novosibirsk Regional Clinical Hospital) with thrombotic complications, the analysis of their medical records were carried out. The homeostasis system parameters, carriage of polymorphic variants of genes predisposing to thrombotic complications were accomplished for the children during the follow-up period. Results and discussion. Thrombotic and/or related ischemic events are more common in premature infants, herewith the severe cerebral ischemia and venous thrombosis localized in various vessels predominated over these complications. The state of the blood coagulation system in children with thrombotic/ischemic events is characterized by hypercoagulation shifts in the external and internal cascades of blood coagulation and accompanied by the increase in the D-dimers level. Among polymorphic variants of genes of hemostasis system the occurrence of polymorphic variant FV Leiden (rs6025) is higher in the study group compared to the European population (χ2 = 7.454; p = 0.025). The obtained data indicate the need for extended diagnostic studies of hemostasis system and genetic search for «thrombogenic» predisposition in children, especially premature, residing in intensive care units for the presence of thrombotic readiness in order to timely predict the development of possible thrombotic and ischemic complications.

Keywords

• thrombosis
• ischemia
• gene polymorphism of the hemostatic system
• full-term and premature children