A novel chalcone derivative from Punica granatum peel inhibits LOX/COX enzyme activity

Abstract

The present study evaluates the Lipoxygenase (LOX) and cyclooxygenase (COX) inhibitory activity of a flavonoid isolated from Punica granatum peel. The molecular structure and chemical bonds were analyzed using UV–Visible, FT-IR, 1H NMR and Mass spectra. The structure of the compound was identified as a novel derivative of chalcone. The isolated compound was interpreted as (2E)-3-(4-hydroxy-3-pentylphenyl)-1-(2-hydroxy-4,5-di((E)-prop-1-enyl)phenyl)prop-2-en-1-one. A prominent inhibition on LOX and COX was observed. The in vitro study indicates the potential of isolated compound to use as an anti-inflammatory agent. Keywords: Punica granatum, Flavonoid, Lipoxygenase, Cyclooxygenase