Pan-cancer analysis reveals the potential of hyaluronate synthase as therapeutic targets in human tumors
Xunxia Bao,
Juan Ran,
Chuifang Kong,
Zunxi Wan,
Juling Wang,
Tengfei Yu,
Shengming Ruan,
Wenjing Ding,
Leiming Xia,
Daoxiang Zhang
Affiliations
Xunxia Bao
School of Life Sciences, Anhui Medical University, Hefei, 230032, China
Juan Ran
School of Life Sciences, Anhui Medical University, Hefei, 230032, China
Chuifang Kong
School of Life Sciences, Anhui Medical University, Hefei, 230032, China
Zunxi Wan
School of Life Sciences, Northeast Normal University, Changchun, 130024, China
Juling Wang
School of Life Sciences, Anhui Medical University, Hefei, 230032, China
Tengfei Yu
School of Life Sciences, Anhui Medical University, Hefei, 230032, China
Shengming Ruan
School of Life Sciences, Anhui Medical University, Hefei, 230032, China
Wenjing Ding
School of Life Sciences, Anhui Medical University, Hefei, 230032, China
Leiming Xia
Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China; Corresponding author.
Daoxiang Zhang
School of Life Sciences, Anhui Medical University, Hefei, 230032, China; Corresponding author. School of Life Sciences, Anhui Medical University, NO.81 Meishan Road, Hefei, 230032, China.
Hyaluronic acid (HA) is a crucial component of the extracellular matrix, and its level of accumulation is related to the progression of various malignant tumors. In this study, a pan-cancer analysis of the three enzymes called hyaluronan synthases (HAS1, HAS2, and HAS3) that produce HA was performed. The study comprehensively describes the characteristics of HAS1, HAS2, and HAS3 in cancers using public databases and tools, to identify the potential biological pathways involved at the molecular, protein, cellular, and clinical sample levels. The analysis showed that dysregulation of the three genes often occurs in cancer, contributing to cancer progression, metastasis, and prognosis. Overexpression of HAS2 promotes secretion of HA in GBM and enhances cell proliferation and migration. The common and specific functions of HAS in certain diseases have important research implications for the treatment and prognosis of tumors.
