Comparison of Coronary Artery Calcium Score and Serum Calcium, Phosphorus, and Gamma-Glutamyl Transferase Levels in Patients with Coronary Artery Imaging by Multi-Sectional Computed Tomography with Chronic Ischemic Heart Disease Prediagnosis

Abstract

Introduction: Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Calcification of the coronary artery wall is a definite indicator of coronary atherosclerosis. Calcium scores in coronary arteries (CAC) can be detected by multidetector computed tomography (MDCT) before any cardiac event occurs. Gamma-glutamyl transferase (GGT) is a biomarker for oxidative stress and a proatherogenic marker for its indirect contribution to the biochemical process resulting in low-density lipoprotein cholesterol oxidation. Studies have shown that serum inorganic phosphorus levels are an independent risk factor for cardiovascular mortality. In our study, we evaluated the correlation between MDCT, CAC score, and the risk of coronary events predicted by evaluating this score according to age, gender, and serum GGT, calcium, and phosphorus levels. Methods: In this retrospective study, 190 patients with a prediagnosis of CAD, laboratory investigations and MDCT were included. Patients were divided into three groups as low, intermediate, and high based on the risk of coronary events determined by the evaluation of CAC scores according to age and gender. Results: In our study, a statistically significant result was found between high serum phosphorus and GGT levels and CAC and coronary event high risk groups classified according to this score (p0.05). Conclusion: The correlation of phosphorus and GGT levels, which are considered independent risk factors for CAD, with CAC, which is an indicator of atherosclerosis in coronary arteries, was significant.

Keywords

• coronary artery calcium score
• calcium
• phosphor
• gamma-glutamyl transferase