Cutaneous adverse drug reactions to lamotrigine and human leukocyte antigen typing in North Indian patients: A case series

Abstract

Cutaneous adverse drug reaction (cADR) has limited epidemiological data in India. The older antiepileptic drugs, i.e., carbamazepine, phenytoin, valproic acid, phenobarbitone, etc., induce severe cADRs that have a strong associated with human leukocyte antigen (HLA)-related genetic risk factors. There is also evidence of association of certain HLA alleles with lamotrigine (LTG)-induced cADRs, but this has not been reported in the Indian population. Here, we report case series of three patients with LTG-induced “Stevens-Johnson syndrome (SJS).” Their HLA-B typing was also performed which showed the presence of HLA-B*15:02 in one case with SJS.

Keywords

• Hypersensitivity
• lamotrigine
• Stevens-Johnson syndrome
• toxic epidermal necrolysis