Stimuli-responsive self-regulating magnetic-thermal materials for selective magnetic hyperthermia therapy

Abstract

Magnetic hyperthermia therapy (MHT) has become an emerging research hotspot in tumor hyperthermia with the superior tissue penetration of alternating magnetic fields. However, due to the inability to precisely control the treatment range, the entire or partial body needs to be heated during treatment, especially for deep and migratory tumors. This will not only cause burning, pain, and even burn to the nerves and muscles around the treatment area but also cause thermal pressure hazards to physiological functions (heat stroke, etc.), significantly increasing the burden on the heart and circulatory system. In response to the above problems, we discussed the options for achieving selective killing of MHT and found the innovative proposal to give the self-regulating magnetic-thermal conversion ability to magnetic material by stimuli-responsive self-assembly at the tumor microenvironment is the best solution to solve the selectivity of MHT.

Keywords

• Magnetic hyperthermia therapy
• Selective killing
• Tumor microenvironment
• Self-assembly
• Self-regulating