Shared functional connectome fingerprints following ritualistic ayahuasca intake
Pablo Mallaroni,
Natasha L. Mason,
Lilian Kloft,
Johannes T. Reckweg,
Kim van Oorsouw,
Stefan W. Toennes,
Hanna M. Tolle,
Enrico Amico,
Johannes G. Ramaekers
Affiliations
Pablo Mallaroni
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands; Corresponding author.
Natasha L. Mason
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands
Lilian Kloft
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands
Johannes T. Reckweg
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands
Kim van Oorsouw
Department of Forensic Psychology, Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands
Stefan W. Toennes
Institute of Legal Medicine, University Hospital, Goethe University, Frankfurt/Main, Germany
Hanna M. Tolle
Neuro-X Institute, EPFL, Geneva, Switzerland
Enrico Amico
Neuro-X Institute, EPFL, Geneva, Switzerland
Johannes G. Ramaekers
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands
The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such “fingerprints” persist under altered states of consciousness is unknown. Ayahuasca is a potent serotonergic psychedelic which produces a widespread dysregulation of functional connectivity. Used communally in religious ceremonies, its shared use may highlight relevant novel interactions between mental state and functional connectome (FC) idiosyncrasy. Using 7T fMRI, we assessed resting-state static and dynamic FCs for 21 Santo Daime members after collective ayahuasca intake in an acute, within-subject study. Here, connectome fingerprinting revealed FCs showed reduced idiosyncrasy, accompanied by a spatiotemporal reallocation of keypoint edges. Importantly, we show that interindividual differences in higher-order FC motifs are relevant to experiential phenotypes, given that they can predict perceptual drug effects. Collectively, our findings offer an example of how individualised connectivity markers can be used to trace a subject's FC across altered states of consciousness.
