Journal for ImmunoTherapy of Cancer (Jun 2020)
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
- Dmitriy Zamarin,
- Howard L Kaufman,
- Dobrin Draganov,
- Sofia R Gameiro,
- Ilio Vitale,
- Sandy Adjemian,
- Aitziber Buqué Martinez,
- Timothy A Chan,
- Richard L Edelson,
- Lucia Gabriele,
- Encouse Golden,
- Kevin J Harrington,
- Dewan Md Sakib Hossain,
- Michael Karin,
- Juan Jose Lasarte,
- Sherene Loi,
- Gwenola Manic,
- Alan A Melcher,
- Karen L Mossman,
- Maria Rescigno,
- Chiara Riganti,
- Antonella Sistigu,
- Bryan E Strauss,
- Kazuki Tatsuno,
- Stefaan W van Gool,
- Peter Vandenabeele
Affiliations
- Dmitriy Zamarin
- Memorial Sloan Kettering Cancer Center, New York City, New York, USA
- Howard L Kaufman
- Surgery, Massachusetts General Hospital and Immuneering Corporation, Boston, Massachusetts, USA
- Dobrin Draganov
- Aff33 Calidi Biotherapeutics San Diego CA USA
- Sofia R Gameiro
- Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
- Ilio Vitale
- IIGM - Italian Institute for Genomic Medicine, c/o IRCSS, Candiolo, Torino, Italy
- Sandy Adjemian
- VIB Center for Inflammation Research (IRC), Ghent, Belgium
- Aitziber Buqué Martinez
- Department of Radiation Oncology, Weill Cornell Medical College, New York City, New York, USA
- Timothy A Chan
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York City, New York, USA
- Richard L Edelson
- Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA
- Lucia Gabriele
- Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
- Encouse Golden
- Department of Radiation Oncology, Weill Cornell Medical College, New York City, New York, USA
- Kevin J Harrington
- Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK
- Dewan Md Sakib Hossain
- Merck & Co. Inc, Kenilworth, New Jersey, USA
- Michael Karin
- Department of Pharmacology and Pathology, University of California at San Diego (UCSD) School of Medicine, La Jolla, California, USA
- Juan Jose Lasarte
- Program of Immunology and Immunotherapy, Centro de Investigación Médica Aplicada (CIMA), University of Navarra, Pamplona, Spain
- Sherene Loi
- Division of Research and Clinical Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
- Gwenola Manic
- IIGM - Italian Institute for Genomic Medicine, c/o IRCSS, Candiolo, Torino, Italy
- Alan A Melcher
- The Institute of Cancer Research, London, UK
- Karen L Mossman
- McMaster University, Hamilton, Ontario, Canada
- Maria Rescigno
- Humanitas Clinical and Research Center – IRCCS, Rozzano, Italy
- Chiara Riganti
- Department of Oncology, University of Torino, Torino, Italy
- Antonella Sistigu
- UOSD Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy
- Bryan E Strauss
- Centro de Investigação Translacional em Oncologia/LIM24, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil
- Kazuki Tatsuno
- Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA
- Stefaan W van Gool
- Immun-Onkologisches Zentrum Köln, Cologne, Germany
- Peter Vandenabeele
- VIB Center for Inflammation Research (IRC), Ghent, Belgium
- DOI
- https://doi.org/10.1136/jitc-2019-000337
- Journal volume & issue
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Vol. 8,
no. 1
Abstract
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.