Journal for ImmunoTherapy of Cancer (May 2020)
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
- Udo S Gaipl,
- Dmitriy Zamarin,
- Felipe Prosper,
- Francesco M Marincola,
- Alessandra Cesano,
- Howard L Kaufman,
- Laurence Zitvogel,
- Tim Illidge,
- Taha Merghoub,
- Sandra Demaria,
- Abhishek D Garg,
- Patrizia Agostinis,
- James W Hodge,
- George Coukos,
- Akseli Hemminki,
- Öystein Rekdal,
- Jian Han,
- John Stagg,
- Sarah Warren,
- Lorenzo Galluzzi,
- Dobrin Draganov,
- Silvia C Formenti,
- Mark J Smyth,
- Radek Špíšek,
- Michael T Lotze,
- Takahiro Yamazaki,
- Guido Kroemer,
- Daolin Tang,
- Eric Deutsch,
- Jitka Fucikova,
- Sofia R Gameiro,
- Ilio Vitale,
- Sandy Adjemian,
- Aitziber Buqué Martinez,
- Timothy A Chan,
- Richard L Edelson,
- Lucia Gabriele,
- Encouse Golden,
- Kevin J Harrington,
- Dewan Md Sakib Hossain,
- Michael Karin,
- Oliver Kepp,
- Juan Jose Lasarte,
- Sherene Loi,
- Gwenola Manic,
- Alan A Melcher,
- Karen L Mossman,
- Maria Rescigno,
- Chiara Riganti,
- Antonella Sistigu,
- Bryan E Strauss,
- Kazuki Tatsuno,
- Stefaan W van Gool,
- Peter Vandenabeele
Affiliations
- Udo S Gaipl
- Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
- Dmitriy Zamarin
- 12 Department of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Felipe Prosper
- Cancer Center Universidad de Navarra (CCUN), Pamplona, Spain
- Francesco M Marincola
- Aff8 grid.467063.00000000403974222Research, Sidra Medical and Research Center Doha Qatar
- Alessandra Cesano
- Aff2 NanoString, Inc 500 Fairview Avenue North 98109 Seattle WA USA
- Howard L Kaufman
- Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
- Laurence Zitvogel
- 1Gustave Roussy, Villejuif, Ile-de-France, France
- Tim Illidge
- Aff1 grid.5379.80000000121662407University of Manchester Manchester United Kingdom
- Taha Merghoub
- 1Weill Cornell Medical and Graduate Schools, New York, New York, USA
- Sandra Demaria
- Department of Radiation Oncology, Weill Cornell Medical College, New York, New York, USA
- Abhishek D Garg
- Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium
- Patrizia Agostinis
- Department of Cellular and Molecular Medicine, Cell Death Research and Therapy Laboratory, KU Leuven, Belgium
- James W Hodge
- Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
- George Coukos
- Department of Oncology, Ludwig Institute for Cancer Research Lausanne, Lausanne University Hospital and University of Lausanne, Lausanne, Vaud, Switzerland
- Akseli Hemminki
- 2Cancer Gene Therapy Group, Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
- Öystein Rekdal
- Aff1 Lytixbiopharma, Oslo, Norway Oslo Norway
- Jian Han
- Shanxi Dayi Hospital, Rheumatology, Taiyuan, China
- John Stagg
- Faculty of Pharmacy, Centre Hospitalier de L`Universite de Montreal, Montreal, Quebec, Canada
- Sarah Warren
- Gilead Sciences, Seattle, Washington, USA
- Lorenzo Galluzzi
- Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA
- Dobrin Draganov
- Aff33 Calidi Biotherapeutics San Diego CA USA
- Silvia C Formenti
- Aff2 grid.137628.90000000121698901Radiation OncologyNYU School of Medicine New York NY USA
- Mark J Smyth
- Aff2 grid.1055.10000000403978434Cancer ImmunologyPeter MacCallum Cancer Centre Melbourne VIC Australia
- Radek Špíšek
- Sotio Biotech, Prague, Czech Republic
- Michael T Lotze
- UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, Pennsylvania, USA
- Takahiro Yamazaki
- 1Weill Cornell Medical College, New York, NY, USA
- Guido Kroemer
- 1Gustave Roussy, Villejuif, Ile-de-France, France
- Daolin Tang
- Aff4 grid.21925.3d0000000419369000Department of SurgeryUniversity of Pittsburgh Pittsburgh PA USA
- Eric Deutsch
- INSERM U1030, Gustave Roussy, Université Paris-Saclay, Villejuif, France
- Jitka Fucikova
- Sotio Biotech, Prague, Czech Republic
- Sofia R Gameiro
- Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
- Ilio Vitale
- 6 IIGM - Italian Institute for Genomic Medicine, c/o IRCSS, Candiolo, Torino, Italy
- Sandy Adjemian
- 9 VIB Center for Inflammation Research (IRC), Ghent, Belgium
- Aitziber Buqué Martinez
- 1 Department of Radiation Oncology, Weill Cornell Medical College, New York City, New York, USA
- Timothy A Chan
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
- Richard L Edelson
- 4 Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA
- Lucia Gabriele
- 24 Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
- Encouse Golden
- 1 Department of Radiation Oncology, Weill Cornell Medical College, New York City, New York, USA
- Kevin J Harrington
- Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK
- Dewan Md Sakib Hossain
- 32 Merck & Co. Inc, Kenilworth, New Jersey, USA
- Michael Karin
- 34 Department of Pharmacology and Pathology, University of California at San Diego (UCSD) School of Medicine, La Jolla, California, USA
- Oliver Kepp
- Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France
- Juan Jose Lasarte
- Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, IdISNA, Pamplona, Spain
- Sherene Loi
- 18 Division of Cancer Research, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
- Gwenola Manic
- 6 IIGM - Italian Institute for Genomic Medicine, c/o IRCSS, Candiolo, Torino, Italy
- Alan A Melcher
- Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK
- Karen L Mossman
- Department of Medicine, McMaster University, Hamilton, Ontario, Canada
- Maria Rescigno
- IRCSS Humanitas Research Hospital, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy
- Chiara Riganti
- 1University of Torino, Torino, Piemonte, Italy
- Antonella Sistigu
- 63 UOSD Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy
- Bryan E Strauss
- 69 Centro de Investigação Translacional em Oncologia/LIM24, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil
- Kazuki Tatsuno
- 4 Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA
- Stefaan W van Gool
- 71 Immun-Onkologisches Zentrum Köln, Cologne, Germany
- Peter Vandenabeele
- 9 VIB Center for Inflammation Research (IRC), Ghent, Belgium
- DOI
- https://doi.org/10.1136/jitc-2019-000337
- Journal volume & issue
-
Vol. 8,
no. 1
Abstract
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.
