Frontiers in Microbiology (Jul 2022)

Paratyphoid Fever A: Infection and Prevention

  • Lei Xie,
  • Lan Ming,
  • Manlin Ding,
  • Manlin Ding,
  • Luxin Deng,
  • Miao Liu,
  • Yanguang Cong,
  • Yanguang Cong

DOI
https://doi.org/10.3389/fmicb.2022.945235
Journal volume & issue
Vol. 13

Abstract

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Enteric fever is caused by Salmonella enterica serovar Typhi, Salmonella enterica serovar Paratyphi A, B, and C. While S. Typhi remains the primary causative agent of enteric fever, S. Paratyphi A is responsible for an increasing portion of enteric fever incidence. However, the current available vaccines for enteric fever are all developed from S. Typhi, and lack adequate cross immune protection against paratyphoid fever A. Therefore, paratyphoid A vaccines are urgently needed. The present paper reviews the latest progresses in pathogenesis, global burden, infection features of paratyphoid fever A, as well as the status of vaccine development, highlighting the necessity for the development of vaccines against paratyphoid fever A.

Keywords