One year overall survival of wilms tumor cases and its predictors, among children diagnosed at a teaching hospital in South Western Uganda: a retrospective cohort study
Eddymond Ekuk,
Charles Newton Odongo,
Leevan Tibaijuka,
Felix Oyania,
Walufu Ivan Egesa,
Felix Bongomin,
Raymond Atwiine,
Moses Acan,
Martin Situma
Affiliations
Eddymond Ekuk
Department of Surgery, Mbarara University of Science and Technology, Faculty of Medicine
Charles Newton Odongo
Department of Surgery, Mbarara University of Science and Technology, Faculty of Medicine
Leevan Tibaijuka
Department of Surgery, Mbarara University of Science and Technology, Faculty of Medicine
Felix Oyania
Department of Surgery, Mbarara University of Science and Technology, Faculty of Medicine
Walufu Ivan Egesa
Department of Pediatrics, Faculty of Clinical Medicine and Dentistry, Kampala International
Felix Bongomin
Department of Microbiology, Mycology, and Immunology, Internal Medicine Gulu University
Raymond Atwiine
Department of Surgery, Mbarara University of Science and Technology, Faculty of Medicine
Moses Acan
Department of Surgery, Mbarara University of Science and Technology, Faculty of Medicine
Martin Situma
Department of Surgery, Mbarara University of Science and Technology, Faculty of Medicine
Abstract Background Wilms tumor (WT) is the second most common solid tumor in Africa with both low overall survival (OS) and event-free survival (EFS) rates. However, no known factors are predicting this poor overall survival. Objective The study was to determine the one-year overall survival of WT cases and its predictors among children diagnosed in the pediatric oncology and surgical units of Mbarara regional referral hospital (MRRH), western Uganda. Methodology Children’s treatment charts and files diagnosed and managed for WT were retrospectively followed up for the period between January 2017 to January 2021. Charts of children with histologically confirmed diagnoses were reviewed for demographics, clinical and histological characteristics, as well as treatment modalities. Results One-year overall survival was found to be 59.3% (95% CI: 40.7–73.3), with tumor size greater than 15 cm (p 0.021) and unfavorable WT type (p 0.012) being the predominant predictors. Conclusion Overall survival (OS) of WT at MRRH was found to be 59.3%, and predictive factors noted were unfavorable histology and tumor size greater than 115 cm.
