ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling

Xiaoyun Sun; Xixia Peng; Yuqin Cao; Yan Zhou; Yuhua Sun

doi:10.1038/s41467-020-16799-0

Nature Communications (Jun 2020)

ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling

Xiaoyun Sun,
Xixia Peng,
Yuqin Cao,
Yan Zhou,
Yuhua Sun

Affiliations

Xiaoyun Sun: The Innovation of Seed Design, Chinese Academy of Sciences
Xixia Peng: The Innovation of Seed Design, Chinese Academy of Sciences
Yuqin Cao: The Innovation of Seed Design, Chinese Academy of Sciences
Yan Zhou: Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Wuhan University
Yuhua Sun: The Innovation of Seed Design, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-020-16799-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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ADNP has been connected to neural developmental disorders. Here, the authors uncover a role for ADNP in neural induction and differentiation via β-Catenin stabilization, with ADNP disruption in zebrafish leading to defective neurogenesis and decreased Wnt signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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