Frontiers in Human Neuroscience (Aug 2015)

Role of the parahippocampal cortex in memory for the configuration but not the identity of objects: converging evidence from patients with selective thermal lesions and fMRI

  • Veronique D Bohbot,
  • John J.B. Allen,
  • Alain eDagher,
  • Serge O Dumoulin,
  • Alan eEvans,
  • Michael ePetrides,
  • Miroslav eKalina,
  • Katerina eStepankova,
  • Katerina eStepankova,
  • Lynn eNadel,
  • Lynn eNadel

DOI
https://doi.org/10.3389/fnhum.2015.00431
Journal volume & issue
Vol. 9

Abstract

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The parahippocampal cortex and hippocampus are brain structures known to be involved in memory. However, the unique contribution of the parahippocampal cortex remains unclear. The current study investigates memory for object identity and memory of the configuration of objects in patients with small thermo-coagulation lesions to the hippocampus or the parahippocampal cortex. Results showed that in contrast to control participants and patients with damage to the hippocampus leaving the parahippocampal cortex intact, patients with lesions that included the right parahippocampal cortex were severely impaired on a task that required learning the spatial configuration of objects on a computer screen; these patients, however, were not impaired at learning the identity of objects. Conversely, we found that patients with lesions to the right hippocampus or left hippocampus, sparing the parahippocampal cortex, performed just as well as the control participants. Furthermore, they were not impaired on the object identity task. In the fMRI experiment, healthy young adults performed the same tasks. Consistent with the findings of the lesion study, the fMRI results showed significant activity in the right parahippocampal cortex in the memory for the spatial configuration condition, but not memory for object identity. Furthermore, the pattern of fMRI activity measured in the baseline control conditions decreased specifically in the parahippocampal cortex as a result of the experimental task, providing evidence for task specific repetition suppression. In summary, while our previous studies demonstrated that the hippocampus is critical to the construction of a cognitive map, both the lesion and fMRI studies have shown an involvement of the right parahippocampal cortex for learning spatial configurations of objects but not object identity, and that this takes place independent of the hippocampus.

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