Cancers (Feb 2021)
The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer
- Jennifer B. Permuth,
- Kaleena B. Dezsi,
- Shraddha Vyas,
- Karla N. Ali,
- Toni L. Basinski,
- Ovie A. Utuama,
- Jason W. Denbo,
- Jason Klapman,
- Aamir Dam,
- Estrella Carballido,
- Dae Won Kim,
- Jose M. Pimiento,
- Benjamin D. Powers,
- Amy K. Otto,
- Jung W. Choi,
- Dung-Tsa Chen,
- Jamie K. Teer,
- Francisca Beato,
- Alina Ward,
- Elena M. Cortizas,
- Suzanne Y. Whisner,
- Iverson E. Williams,
- Andrea N. Riner,
- Kenneth Tardif,
- Vic Velanovich,
- Andreas Karachristos,
- Wade G. Douglas,
- Adrian Legaspi,
- Bassan J. Allan,
- Kenneth Meredith,
- Manual A. Molina-Vega,
- Philip Bao,
- Jamii St. Julien,
- Kevin L. Huguet,
- Lee Green,
- Folakemi T. Odedina,
- Nagi B. Kumar,
- Vani N. Simmons,
- Thomas J. George,
- Susan T. Vadaparampil,
- Pamela J. Hodul,
- J. Pablo Arnoletti,
- Ziad T. Awad,
- Debashish Bose,
- Kun Jiang,
- Barbara A. Centeno,
- Clement K. Gwede,
- Mokenge Malafa,
- Sarah M. Judge,
- Andrew R. Judge,
- Daniel Jeong,
- Mark Bloomston,
- Nipun B. Merchant,
- Jason B. Fleming,
- Jose G. Trevino,
- on behalf of the Florida Pancreas Collaborative
Affiliations
- Jennifer B. Permuth
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Kaleena B. Dezsi
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Shraddha Vyas
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Karla N. Ali
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Toni L. Basinski
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Ovie A. Utuama
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Jason W. Denbo
- Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Jason Klapman
- Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Aamir Dam
- Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Estrella Carballido
- Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Dae Won Kim
- Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Jose M. Pimiento
- Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Benjamin D. Powers
- Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Amy K. Otto
- Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL 33612, USA
- Jung W. Choi
- Department of Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Dung-Tsa Chen
- Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Jamie K. Teer
- Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Francisca Beato
- Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Alina Ward
- Lee Health Regional Cancer Center, Fort Myers, FL 33905, USA
- Elena M. Cortizas
- Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
- Suzanne Y. Whisner
- Cancer Institute, Advent Health Orlando, Orlando, FL 32804, USA
- Iverson E. Williams
- College of Medicine, University of Florida, Gainesville, FL 32610, USA
- Andrea N. Riner
- College of Medicine, University of Florida, Gainesville, FL 32610, USA
- Kenneth Tardif
- Department of Surgery, St. Anthony’s Hospital, St. Petersburg, FL 33705, USA
- Vic Velanovich
- Tampa General Hospital, University of South Florida, Tampa, FL 33606, USA
- Andreas Karachristos
- Tampa General Hospital, University of South Florida, Tampa, FL 33606, USA
- Wade G. Douglas
- Division of Surgery, Tallahassee Memorial Healthcare, Department of Clinical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32308, USA
- Adrian Legaspi
- Center for Advanced Surgical Oncology at Palmetto General Hospital, Tenet Healthcare Palmetto General, Hialeah, FL 33016, USA
- Bassan J. Allan
- Lee Health Regional Cancer Center, Fort Myers, FL 33905, USA
- Kenneth Meredith
- Department of Gastrointestinal Oncology, Brian Jellison Cancer Institute, Sarasota Memorial Hospital, Sarasota, FL 34239, USA
- Manual A. Molina-Vega
- Lakeland Regional Health, Lakeland, FL 33805, USA
- Philip Bao
- Department of Surgical Oncology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
- Jamii St. Julien
- Department of Surgery, St. Anthony’s Hospital, St. Petersburg, FL 33705, USA
- Kevin L. Huguet
- Department of Surgery, St. Anthony’s Hospital, St. Petersburg, FL 33705, USA
- Lee Green
- Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Folakemi T. Odedina
- Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA
- Nagi B. Kumar
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Vani N. Simmons
- Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Thomas J. George
- Division of Oncology, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
- Susan T. Vadaparampil
- Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Pamela J. Hodul
- Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- J. Pablo Arnoletti
- Center for Surgical Oncology, Advent Health Orlando, Orlando, FL 32804, USA
- Ziad T. Awad
- Surgery, University of Florida-Jacksonville, Jacksonville, FL 32209, USA
- Debashish Bose
- Surgical Oncology, University of Florida-Orlando, Orlando, FL 32806, USA
- Kun Jiang
- Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Barbara A. Centeno
- Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Clement K. Gwede
- Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Mokenge Malafa
- Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Sarah M. Judge
- Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA
- Andrew R. Judge
- Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA
- Daniel Jeong
- Department of Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Mark Bloomston
- Lee Health Regional Cancer Center, Fort Myers, FL 33905, USA
- Nipun B. Merchant
- Department of Surgical Oncology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
- Jason B. Fleming
- Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
- Jose G. Trevino
- College of Medicine, University of Florida, Gainesville, FL 32610, USA
- on behalf of the Florida Pancreas Collaborative
- DOI
- https://doi.org/10.3390/cancers13040809
- Journal volume & issue
-
Vol. 13,
no. 4
p. 809
Abstract
Background: Well-annotated, high-quality biorepositories provide a valuable platform to support translational research. However, most biorepositories have poor representation of minority groups, limiting the ability to address health disparities. Methods: We describe the establishment of the Florida Pancreas Collaborative (FPC), the first state-wide prospective cohort study and biorepository designed to address the higher burden of pancreatic cancer (PaCa) in African Americans (AA) compared to Non-Hispanic Whites (NHW) and Hispanic/Latinx (H/L). We provide an overview of stakeholders; study eligibility and design; recruitment strategies; standard operating procedures to collect, process, store, and transfer biospecimens, medical images, and data; our cloud-based data management platform; and progress regarding recruitment and biobanking. Results: The FPC consists of multidisciplinary teams from fifteen Florida medical institutions. From March 2019 through August 2020, 350 patients were assessed for eligibility, 323 met inclusion/exclusion criteria, and 305 (94%) enrolled, including 228 NHW, 30 AA, and 47 H/L, with 94%, 100%, and 94% participation rates, respectively. A high percentage of participants have donated blood (87%), pancreatic tumor tissue (41%), computed tomography scans (76%), and questionnaires (62%). Conclusions: This biorepository addresses a critical gap in PaCa research and has potential to advance translational studies intended to minimize disparities and reduce PaCa-related morbidity and mortality.
Keywords
