Atopic dermatitis: pathogenesis and therapeutic intervention
Chengcheng Yue,
Hong Zhou,
Xiaoyan Wang,
Jiadong Yu,
Yawen Hu,
Pei Zhou,
Fulei Zhao,
Fanlian Zeng,
Guolin Li,
Ya Li,
Yuting Feng,
Xiaochi Sun,
Shishi Huang,
Mingxiang He,
Wenling Wu,
Nongyu Huang,
Jiong Li
Affiliations
Chengcheng Yue
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Hong Zhou
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Xiaoyan Wang
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Jiadong Yu
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Yawen Hu
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Pei Zhou
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Fulei Zhao
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Fanlian Zeng
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Guolin Li
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Ya Li
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Yuting Feng
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Xiaochi Sun
Department of Cardiology West China Hospital Sichuan University Chengdu Sichuan China
Shishi Huang
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Mingxiang He
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Wenling Wu
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Nongyu Huang
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Jiong Li
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China
Abstract The skin serves as the first protective barrier for nonspecific immunity and encompasses a vast network of skin‐associated immune cells. Atopic dermatitis (AD) is a prevalent inflammatory skin disease that affects individuals of all ages and races, with a complex pathogenesis intricately linked to genetic, environmental factors, skin barrier dysfunction as well as immune dysfunction. Individuals diagnosed with AD frequently exhibit genetic predispositions, characterized by mutations that impact the structural integrity of the skin barrier. This barrier dysfunction leads to the release of alarmins, activating the type 2 immune pathway and recruiting various immune cells to the skin, where they coordinate cutaneous immune responses. In this review, we summarize experimental models of AD and provide an overview of its pathogenesis and the therapeutic interventions. We focus on elucidating the intricate interplay between the immune system of the skin and the complex regulatory mechanisms, as well as commonly used treatments for AD, aiming to systematically understand the cellular and molecular crosstalk in AD‐affected skin. Our overarching objective is to provide novel insights and inform potential clinical interventions to reduce the incidence and impact of AD.
