Short-term nitisinone discontinuation of hereditary tyrosinemia type 1 mice causes metabolic alterations in glutathione metabolism/biosynthesis and multiple amino acid degradation pathways

• Colemonts-Vroninks Haaike,
• Norman P. Brendan,
• Van Laere Sven,
• Davison S. Andrew,
• Marcélis Lionel,
• Casimir Georges,
• Goyens Philippe,
• Claes Paul,
• De Bundel Dimitri,
• Martens Geert,
• Ranganath Lakshminarayan Rao,
• Vanhaecke Tamara,
• Gallagher James A,
• De Kock Joery

Affiliations

Colemonts-Vroninks Haaike

Vrije Universiteit Brussel, Liver Therapy & Evolution Team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) Research Group, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium; Vrije Universiteit Brussel, Experimental Pharmacology (EFAR) Research Group, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium; Corresponding author. Vrije Universiteit Brussel, Liver Therapy & Evolution team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) research group, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium.

Norman P. Brendan

University of Liverpool, Dept. of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences, Liverpool L7 8TX, United Kingdom

Van Laere Sven

Vrije Universiteit Brussel, Interfaculty Center Data Processing and Statistics, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium

Davison S. Andrew

University of Liverpool, Dept. of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences, Liverpool L7 8TX, United Kingdom; Liverpool University Hospitals NHS Foundation Trust, Clinical Biochemistry and Metabolic Medicine, Liverpool L3 5PS, United Kingdom

Marcélis Lionel

Université Libre de Bruxelles, Laboratoire de Pédiatrie, Brussels B-1050, Belgium

Casimir Georges

Université Libre de Bruxelles, Laboratoire de Pédiatrie, Brussels B-1050, Belgium

Goyens Philippe

Université Libre de Bruxelles, Laboratoire de Pédiatrie, Brussels B-1050, Belgium

Claes Paul

Vrije Universiteit Brussel, In Vitro Liver Disease Modelling Team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) Research Group, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium

De Bundel Dimitri

Vrije Universiteit Brussel, Experimental Pharmacology (EFAR) Research Group, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium

Martens Geert

AZ Delta General Hospital, Department of Laboratory Medicine, Roeselare 8800, Belgium; Ghent University, Department of Biomolecular Medicine, Ghent 9052, Belgium

Ranganath Lakshminarayan Rao

Liverpool University Hospitals NHS Foundation Trust, Clinical Biochemistry and Metabolic Medicine, Liverpool L3 5PS, United Kingdom

Vanhaecke Tamara

Vrije Universiteit Brussel, In Vitro Liver Disease Modelling Team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) Research Group, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium

Gallagher James A

University of Liverpool, Dept. of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences, Liverpool L7 8TX, United Kingdom

De Kock Joery

Vrije Universiteit Brussel, Liver Therapy & Evolution Team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) Research Group, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium