Nature Communications (Jan 2021)

A CD8+ NK cell transcriptomic signature associated with clinical outcome in relapsing remitting multiple sclerosis

  • Eoin F. McKinney,
  • Iona Cuthbertson,
  • Kristina M. Harris,
  • Dawn E. Smilek,
  • Christopher Connor,
  • Giulia Manferrari,
  • Edward J. Carr,
  • Scott S. Zamvil,
  • Kenneth G. C. Smith

DOI
https://doi.org/10.1038/s41467-020-20594-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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A better understanding of how multiple sclerosis (MS) can relapse and remit is needed for the identification of biomarkers and better therapeutics. Here the authors identify a CD8 + NK cell population in patients with relapsing remitting MS and validate its association with clinical outcome.