Nature Communications (May 2018)
Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation
- Tingjun Lei,
- Peixuan Zhang,
- Xudong Zhang,
- Xue Xiao,
- Jingli Zhang,
- Tong Qiu,
- Qian Dai,
- Yujun Zhang,
- Ling Min,
- Qian Li,
- Rutie Yin,
- Ping Ding,
- Ni Li,
- Yi Qu,
- Dezhi Mu,
- Jun Qin,
- Xiaofeng Zhu,
- Zhi-Xiong Xiao,
- Qintong Li
Affiliations
- Tingjun Lei
- Department of Obstetrics and Gynecology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University
- Peixuan Zhang
- Department of Obstetrics and Gynecology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University
- Xudong Zhang
- Department of Obstetrics and Gynecology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University
- Xue Xiao
- Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University
- Jingli Zhang
- Department of Pathology, Hospital 363 of Aviation Industry Corporation of China
- Tong Qiu
- Department of Pediatrics, West China Second University Hospital, Sichuan University
- Qian Dai
- Department of Pediatrics, West China Second University Hospital, Sichuan University
- Yujun Zhang
- Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University
- Ling Min
- Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University
- Qian Li
- Department of Pathology, Hospital 363 of Aviation Industry Corporation of China
- Rutie Yin
- Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University
- Ping Ding
- Sichuan Cunde Therapeutics
- Ni Li
- Key Laboratory of Stem Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences
- Yi Qu
- Department of Pediatrics, West China Second University Hospital, Sichuan University
- Dezhi Mu
- Department of Pediatrics, West China Second University Hospital, Sichuan University
- Jun Qin
- Key Laboratory of Stem Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences
- Xiaofeng Zhu
- Department of Obstetrics and Gynecology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University
- Zhi-Xiong Xiao
- Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University
- Qintong Li
- Department of Obstetrics and Gynecology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University
- DOI
- https://doi.org/10.1038/s41467-018-04258-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Prereplicative complex (pre-RC) formation during G1 is fundamental for cell replication. Here the authors report a role for cyclin K in regulating pre-RC formation in mammalian cells by affecting cyclin E1 activity.
