The Clinical Respiratory Journal (Nov 2022)
Assessment of variables associated with prolonged admission duration in children with Mycoplasma pneumoniae pneumonia
- Myongsoon Sung,
- Eui Jeong Roh,
- Eun Sil Lee,
- Ji Young Lee,
- Hyo‐Bin Kim,
- Youngmin Ahn,
- Byung Wook Eun,
- Ja Kyoung Kim,
- Hyoung Young Kim,
- Sung‐Su Jung,
- Minji Kim,
- Eun Kyeong Kang,
- Eun‐Ae Yang,
- Soo Jin Lee,
- Yang Park,
- Ju‐Hee Seo,
- Eun Lee,
- Eun Seok Yang,
- Hyung Min Cho,
- Meeyong Shin,
- Hai Lee Chung,
- Yoon Young Jang,
- Bong Seok Choi,
- Hyeona Kim,
- Jin‐A Jung,
- Seung Taek You,
- Mi‐Hee Lee,
- Jin Tack Kim,
- Bong Seong Kim,
- Yoon Ha Hwang,
- Jung Yeon Shim,
- Hyeon‐Jong Yang,
- Man Yong Han,
- Hae Young Yew,
- Dong Hyeok Kim,
- Sang Oun Jeong,
- Kyujam Whang,
- Eunjoo Lee,
- You Hoon Jeon,
- Eun Hee Chung
Affiliations
- Myongsoon Sung
- Department of Pediatrics Soonchunhyang University Hospital Gumi South Korea
- Eui Jeong Roh
- Department of Pediatrics Chungnam National University Hospital Daejeon South Korea
- Eun Sil Lee
- Department of Pediatrics Chungnam National University Hospital Daejeon South Korea
- Ji Young Lee
- Department of Pediatrics Hallym University Chuncheon Sacred Heart Hospital Chuncheon South Korea
- Hyo‐Bin Kim
- Department of Pediatrics Inje University Sanggye Paik Hospital Seoul South Korea
- Youngmin Ahn
- Department of Pediatrics Eulji University Hospital Seoul South Korea
- Byung Wook Eun
- Department of Pediatrics Eulji University Hospital Seoul South Korea
- Ja Kyoung Kim
- Department of Pediatrics Kangwon National University School of Medicine Chuncheon South Korea
- Hyoung Young Kim
- Department of Pediatrics Pusan National University Children's Hospital, Pusan National University School of Medicine Yangsan South Korea
- Sung‐Su Jung
- Department of Pediatrics Pusan National University Children's Hospital, Pusan National University School of Medicine Yangsan South Korea
- Minji Kim
- Department of Pediatrics, Chungnam University Sejeong Hospital Chungnam National University College of Medicine Sejong South Korea
- Eun Kyeong Kang
- Department of Pediatrics Dongguk University Ilsan Hospital Goyang South Korea
- Eun‐Ae Yang
- Department of Pediatrics, Daejeon St. Mary's Hospital, College of Medicine The Catholic University of Korea Daejeon South Korea
- Soo Jin Lee
- Department of Pediatrics Eulji University Hospital Daejeon South Korea
- Yang Park
- Department of Pediatrics Wonkwang University School of Medicine Iksan South Korea
- Ju‐Hee Seo
- Department of Pediatrics Dankook University College of Medicine Cheonan South Korea
- Eun Lee
- Department of Pediatrics Chonnam National University Hostpital, Chonnam National University Medical School Gwangju South Korea
- Eun Seok Yang
- Department of Pediatrics College of Medicine, Chosun University, Chosun University Hospital, Gwangju, South Korea Gwangju South Korea
- Hyung Min Cho
- Department of Pediatrics Presbyterian Medical Center Jeonju South Korea
- Meeyong Shin
- Department of Pediatrics Soonchunhyang University Bucheon Hospital Bucheon South Korea
- Hai Lee Chung
- Department of Pediatrics Daegu Catholic University Medical Center Daegu South Korea
- Yoon Young Jang
- Department of Pediatrics Daegu Catholic University Medical Center Daegu South Korea
- Bong Seok Choi
- Department of Pediatrics School of Medicine, Kyungpook National University Daegu South Korea
- Hyeona Kim
- Department of Pediatrics School of Medicine, Kyungpook National University Daegu South Korea
- Jin‐A Jung
- Department of Pediatrics Donga‐A University College of Medicine Busan South Korea
- Seung Taek You
- Department of Pediatrics Wonkwang University School of Medicine Iksan South Korea
- Mi‐Hee Lee
- Department of Pediatrics Incheon Medical Center Incheon South Korea
- Jin Tack Kim
- Department of Pediatrics College of Medicine, The Catholic University of Korea, Uijeongbu St. Mary's Hospital Uijeongbu South Korea
- Bong Seong Kim
- Department of Pediatrics University of Ulsan College of Medicine, Gangneung Asan Hospital Gangneung South Korea
- Yoon Ha Hwang
- Department of Pediatrics Busan ST. Mary's Hospital Busan South Korea
- Jung Yeon Shim
- Department of Pediatrics Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital Seoul South Korea
- Hyeon‐Jong Yang
- Department of Pediatrics Soonchunhyang University Hospital Seoul South Korea
- Man Yong Han
- Department of Pediatrics, CHA Bundang Medical Center CHA University School of Medicine Seongnam South Korea
- Hae Young Yew
- Department of Pediatrics Kogel Hospital Daejeon South Korea
- Dong Hyeok Kim
- Divison of Bacterial Diseases Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency (KDCA) Sejong South Korea
- Sang Oun Jeong
- Divison of Bacterial Diseases Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency (KDCA) Sejong South Korea
- Kyujam Whang
- Divison of Bacterial Diseases Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency (KDCA) Sejong South Korea
- Eunjoo Lee
- Department of Pediatrics Inje University Haeundae Paik Hospital Busan South Korea
- You Hoon Jeon
- Department of Pediatrics Hallym University Dongtan Sacred Heart Hospital Hwasung South Korea
- Eun Hee Chung
- Department of Pediatrics Chungnam National University College of Medicine Daejeon South Korea
- DOI
- https://doi.org/10.1111/crj.13549
- Journal volume & issue
-
Vol. 16,
no. 11
pp. 756 – 767
Abstract
Abstract Introduction Macrolide‐resistant Mycoplasma pneumoniae (MRMP) has become prevalent in children. This study investigated the clinical and laboratory variables of MRMP and macrolide‐sensitive M. pneumoniae (MSMP) and identified factors associated with prolonged hospital admission in children. Methods A prospective multicenter study was conducted in 1063 children <18 years old in July 2018–June 2020. The 454 had a positive M. pneumoniae polymerase chain reaction assay. Results Most subjects had MRMP (78.4%), and all mutated strains had the A2063G transition. We defined MRMP* (n = 285) as MRMP pneumonia requiring admission and MSMP* (n = 72) as MSMP pneumonia requiring admission. Patients with MRMP pneumonia were older, more likely to have segmental/lobar pneumonia, and had more febrile days than those with MSMP pneumonia. C‐reactive protein (CRP), lactate dehydrogenase (LDH), and percentage neutrophils were more strongly associated with MRMP* than MSMP* groups. Percentage neutrophils, CRP, and alanine aminotransferase significantly changed between admission and follow‐up measurements in patients with MRMP* (P < 0.05). The duration of admission positively correlated with the number of febrile days after initiation of antibiotic medication and laboratory variables (white blood cell count, CRP, and aspartate aminotransferase [AST]) (P < 0.05). Random forest analysis indicated that the number of febrile days after initiation of antibiotic medication, AST, and percentage neutrophils at admission was over five. Conclusions This study indicated that children with M. pneumoniae pneumonia with a higher number of febrile days after initiation of antibiotic medication, AST, and percentage neutrophils at admission were more likely to have prolonged admission duration.
Keywords
- aspartate aminotransferase
- children
- M. pneumoniae
- macrolide‐resistant M. pneumoniae
- neutrophil portion
