G3: Genes, Genomes, Genetics (Dec 2022)

Gene amplification mutations originate prior to selective stress in <i>Acinetobacter baylyi</i>

  • Jennifer A Herrmann,
  • Agata Koprowska,
  • Tesa J Winters,
  • Nancy Villanueva,
  • Victoria D Nikityuk,
  • Feini Pek,
  • Elizabeth M Reis,
  • Constancia Z Dominguez,
  • Daniel Davis,
  • Eric McPherson,
  • Staci R Rocco,
  • Cynthia Recendez,
  • Shyla M Difuntorum,
  • Kelly Faeth,
  • Mario D Lopez,
  • Habeeba M Awwad,
  • Rola A Ghobashy,
  • Lauren Cappiello,
  • Ellen L Neidle,
  • Semarhy Quiñones-Soto,
  • Andrew B Reams

DOI
https://doi.org/10.1093/g3journal/jkac327
Journal volume & issue
Vol. 13, no. 3

Abstract

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AbstractThe controversial theory of adaptive amplification states gene amplification mutations are induced by selective environments where they are enriched due to the stress caused by growth restriction on unadapted cells. We tested this theory with three independent assays using an Acinetobacter baylyicatcatAcinetobacter