The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction

Guanlan Hu; Catriona Ling; Lijun Chi; Mehakpreet K. Thind; Samuel Furse; Albert Koulman; Jonathan R. Swann; Dorothy Lee; Marjolein M. Calon; Celine Bourdon; Christian J. Versloot; Barbara M. Bakker; Gerard Bryan Gonzales; Peter K. Kim; Robert H. J. Bandsma

doi:10.1038/s41467-022-35317-y

Nature Communications (Dec 2022)

The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction

Guanlan Hu,
Catriona Ling,
Lijun Chi,
Mehakpreet K. Thind,
Samuel Furse,
Albert Koulman,
Jonathan R. Swann,
Dorothy Lee,
Marjolein M. Calon,
Celine Bourdon,
Christian J. Versloot,
Barbara M. Bakker,
Gerard Bryan Gonzales,
Peter K. Kim,
Robert H. J. Bandsma

Affiliations

Guanlan Hu: Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto
Catriona Ling: Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto
Lijun Chi: Translational Medicine Program, The Hospital for Sick Children
Mehakpreet K. Thind: Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto
Samuel Furse: Core Metabolomics and Lipidomics Laboratory, Wellcome Trust-Metabolic Research Laboratories, Institute of Metabolic Sciences, University of Cambridge
Albert Koulman: Core Metabolomics and Lipidomics Laboratory, Wellcome Trust-Metabolic Research Laboratories, Institute of Metabolic Sciences, University of Cambridge
Jonathan R. Swann: School of Human Development and Health, Faculty of Medicine, University of Southampton
Dorothy Lee: Translational Medicine Program, The Hospital for Sick Children
Marjolein M. Calon: Translational Medicine Program, The Hospital for Sick Children
Celine Bourdon: Translational Medicine Program, The Hospital for Sick Children
Christian J. Versloot: Laboratory of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University of Groningen, University Medical Center Groningen
Barbara M. Bakker: Laboratory of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University of Groningen, University Medical Center Groningen
Gerard Bryan Gonzales: Translational Medicine Program, The Hospital for Sick Children
Peter K. Kim: Department of Biochemistry, University of Toronto
Robert H. J. Bandsma: Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto

DOI: https://doi.org/10.1038/s41467-022-35317-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Impaired liver metabolic function is related to mortality in severely malnourished children. Here the authors report a role for the tryptophan-NAD + pathway in reduced hepatic mitochondrial function and liver steatosis in a mouse model of severe malnutrition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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