mBio
(Feb 2021)
RanDeL-Seq: a High-Throughput Method to Map Viral
<i>cis</i>
- and
<i>trans</i>
-Acting Elements
Timothy Notton,
Joshua J. Glazier,
Victoria R. Saykally,
Cassandra E. Thompson,
Leor S. Weinberger
Affiliations
Timothy Notton
Gladstone Center for Cell Circuitry, Gladstone Institutes, San Francisco, California, USA
Joshua J. Glazier
Gladstone Center for Cell Circuitry, Gladstone Institutes, San Francisco, California, USA
Victoria R. Saykally
Gladstone Center for Cell Circuitry, Gladstone Institutes, San Francisco, California, USA
Cassandra E. Thompson
Gladstone Center for Cell Circuitry, Gladstone Institutes, San Francisco, California, USA
Leor S. Weinberger
ORCiD Gladstone Center for Cell Circuitry, Gladstone Institutes, San Francisco, California, USA
DOI
https://doi.org/10.1128/mBio.01724-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Recent studies have renewed interest in developing novel antiviral therapeutics and vaccines based on defective interfering particles (DIPs)—a subset of viral deletion mutants that conditionally replicate. Identifying and engineering DIPs require that viral cistrans
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