Nature Communications (Apr 2016)

High-dimensional genomic data bias correction and data integration using MANCIE

  • Chongzhi Zang,
  • Tao Wang,
  • Ke Deng,
  • Bo Li,
  • Sheng’en Hu,
  • Qian Qin,
  • Tengfei Xiao,
  • Shihua Zhang,
  • Clifford A. Meyer,
  • Housheng Hansen He,
  • Myles Brown,
  • Jun S. Liu,
  • Yang Xie,
  • X. Shirley Liu

DOI
https://doi.org/10.1038/ncomms11305
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 8

Abstract

Read online

Analyses of data from high-throughput genomic technologies are challenging given large data dimensionality. Here, Liu and colleagues describe a method called MANCIE (Matrix Analysis and Normalization by Concordant Information Enhancement) that can conduct genomic data normalization and bias correction to detect biologically relevant information.