Frontiers in Immunology (Jan 2022)
Case Report: An Unusual Course of Angiosarcoma After Lung Transplantation
- Saskia Bos,
- Saskia Bos,
- Liesbeth Daniëls,
- Lucienne Michaux,
- Isabelle Vanden Bempt,
- Sascha Vermeer,
- FJ Sherida H Woei-A-Jin,
- Patrick Schöffski,
- Birgit Weynand,
- Raf Sciot,
- Sabine Declercq,
- Laurens J. Ceulemans,
- Laurens J. Ceulemans,
- Laurent Godinas,
- Laurent Godinas,
- Geert M. Verleden,
- Geert M. Verleden,
- Dirk E. Van Raemdonck,
- Dirk E. Van Raemdonck,
- Lieven J. Dupont,
- Lieven J. Dupont,
- Robin Vos,
- Robin Vos,
- the Leuven Lung Transplant Group,
- Jonas Yserbyt,
- Arne P. Neyrinck,
- Veronique Schaevers,
- Bruno Desschans,
- Dirk Claes,
- Karen Denaux,
- Paul De Leyn,
- Herbert Decaluwé,
- Hans Van Veer,
- Lieven Depypere,
- Marie-Paule Emonds
Affiliations
- Saskia Bos
- Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
- Saskia Bos
- Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
- Liesbeth Daniëls
- Histocompatibility and Immunogenetics Laboratory (HILA), Red Cross-Flanders, Mechelen, Belgium
- Lucienne Michaux
- Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium
- Isabelle Vanden Bempt
- Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium
- Sascha Vermeer
- Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium
- FJ Sherida H Woei-A-Jin
- Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, KU Leuven, Leuven, Belgium
- Patrick Schöffski
- Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, KU Leuven, Leuven, Belgium
- Birgit Weynand
- Department of Pathology, University Hospitals Leuven, Leuven, Belgium
- Raf Sciot
- Department of Pathology, University Hospitals Leuven, Leuven, Belgium
- Sabine Declercq
- Department of Pathology, ZNA Middelheim Hospital, Antwerp, Belgium
- Laurens J. Ceulemans
- Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
- Laurens J. Ceulemans
- Department of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium
- Laurent Godinas
- Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
- Laurent Godinas
- Department of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium
- Geert M. Verleden
- Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
- Geert M. Verleden
- Department of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium
- Dirk E. Van Raemdonck
- Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
- Dirk E. Van Raemdonck
- Department of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium
- Lieven J. Dupont
- Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
- Lieven J. Dupont
- Department of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium
- Robin Vos
- Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
- Robin Vos
- Department of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium
- the Leuven Lung Transplant Group
- Jonas Yserbyt
- Arne P. Neyrinck
- Veronique Schaevers
- Bruno Desschans
- Dirk Claes
- Karen Denaux
- Paul De Leyn
- Herbert Decaluwé
- Hans Van Veer
- Lieven Depypere
- Marie-Paule Emonds
- DOI
- https://doi.org/10.3389/fimmu.2021.789851
- Journal volume & issue
-
Vol. 12
Abstract
A 35-year-old woman underwent bilateral lung transplantation for primary ciliary dyskinesia and developed vascular tumors over a slow time course. Initial presentation of non-specific vascular tumors in the lungs and liver for up to 6 years after transplantation evolved toward bilateral ovarian angiosarcoma. Tumor analysis by haplotyping and human leukocyte antigen typing showed mixed donor chimerism, proving donor origin of the tumoral lesions. In retrospect, the donor became brain dead following neurosurgical complications for a previously biopsy-proven cerebral hemangioma, which is believed to have been a precursor lesion of the vascular malignancy in the recipient. Donor-transmitted tumors should always be suspected in solid organ transplant recipients in case of uncommon disease course or histology, and proper tissue-based diagnosis using sensitive techniques should be pursued.
Keywords
