An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives

Leonardo Schirone; Maurizio Forte; Luca D’Ambrosio; Valentina Valenti; Daniele Vecchio; Sonia Schiavon; Giulia Spinosa; Gianmarco Sarto; Vincenzo Petrozza; Giacomo Frati; Sebastiano Sciarretta

doi:10.3390/cells11071165

Cells (Mar 2022)

An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives

Leonardo Schirone,
Maurizio Forte,
Luca D’Ambrosio,
Valentina Valenti,
Daniele Vecchio,
Sonia Schiavon,
Giulia Spinosa,
Gianmarco Sarto,
Vincenzo Petrozza,
Giacomo Frati,
Sebastiano Sciarretta

Affiliations

Leonardo Schirone: Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Maurizio Forte: IRCCS Neuromed, 86077 Pozzilli, Italy
Luca D’Ambrosio: Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Valentina Valenti: Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Daniele Vecchio: Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Sonia Schiavon: Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Giulia Spinosa: Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Gianmarco Sarto: Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Vincenzo Petrozza: Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Giacomo Frati: Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
Sebastiano Sciarretta: IRCCS Neuromed, 86077 Pozzilli, Italy

DOI: https://doi.org/10.3390/cells11071165
Journal volume & issue: Vol. 11, no. 7
p. 1165

Abstract

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Cardiovascular disease is the leading cause of death in western countries. Among cardiovascular diseases, myocardial infarction represents a life-threatening condition predisposing to the development of heart failure. In recent decades, much effort has been invested in studying the molecular mechanisms underlying the development and progression of ischemia/reperfusion (I/R) injury and post-ischemic cardiac remodeling. These mechanisms include metabolic alterations, ROS overproduction, inflammation, autophagy deregulation and mitochondrial dysfunction. This review article discusses the most recent evidence regarding the molecular basis of myocardial ischemic injury and the new potential therapeutic interventions for boosting cardioprotection and attenuating cardiac remodeling.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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Abstract

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