The effect of C60 fullerene on the mechanokinetics of muscle gastrocnemius contraction in chronically alcoholized rats
Olexandr Motuziuk,
Dmytro Nozdrenko,
Svitlana Prylutska,
Igor Vareniuk,
Kateryna Bogutska,
Serhii Braniuk,
Olexandr Korotkyi,
Yuriy Prylutskyy,
Uwe Ritter,
Jacek Piosik
Affiliations
Olexandr Motuziuk
Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University, Lutsk, 43025, Ukraine; Department of Biophysics and Medical Informatics, ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine
Dmytro Nozdrenko
Department of Biophysics and Medical Informatics, ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine
Svitlana Prylutska
Department of Physiology, Plant Biochemistry and Bioenergetics, Faculty of Plant Protection, Biotechnology and Ecology, National University of Life and Environmental Science of Ukraine, Kyiv, 03041, Ukraine
Igor Vareniuk
Department of Biophysics and Medical Informatics, ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine
Kateryna Bogutska
Department of Biophysics and Medical Informatics, ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine
Serhii Braniuk
Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University, Lutsk, 43025, Ukraine
Olexandr Korotkyi
Department of Biophysics and Medical Informatics, ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine
Yuriy Prylutskyy
Department of Biophysics and Medical Informatics, ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine; Corresponding author.
Uwe Ritter
Institute of Chemistry and Biotechnology, Technical University of Ilmenau, Ilmenau, 98693, Germany
Jacek Piosik
Intercollegiate Faculty of Biotechnology, University of Gdansk, 80-307, Gdańsk, Poland; Corresponding author.
The C60 fullerene effect (oral administration at a dose of 1 mg kg−1) on the selected biomechanical parameters of muscle gastrocnemius contraction, biochemical indicators of blood and muscle tissue as well as histological changes in rat muscle tissue after chronic alcoholization for 3, 6 and 9 months was studied in detail. Water-soluble C60 fullerenes were shown to reduce the pathological processes development in the muscle apparatus by an average of (35–40)%. In particular, they reduced the time occurrence of fatigue processes in muscle during the long-term development of alcoholic myopathy and inhibited oxidative processes in muscle, thereby preventing its degradation. These findings open up the possibility of using C60 fullerenes as potent antioxidants for the correction of the pathological conditions of the muscle system arising from alcohol intoxication.
