Bacteriophage T4 Escapes CRISPR Attack by Minihomology Recombination and Repair

Xiaorong Wu; Jingen Zhu; Pan Tao; Venigalla B. Rao

doi:10.1128/mBio.01361-21

mBio (Jun 2021)

Bacteriophage T4 Escapes CRISPR Attack by Minihomology Recombination and Repair

Xiaorong Wu,
Jingen Zhu,
Pan Tao,
Venigalla B. Rao

Affiliations

Xiaorong Wu: Bacteriophage Medical Research Center, Department of Biology, The Catholic University of America, Washington, DC, USA
Jingen Zhu: Bacteriophage Medical Research Center, Department of Biology, The Catholic University of America, Washington, DC, USA
Pan Tao: ORCiD; Bacteriophage Medical Research Center, Department of Biology, The Catholic University of America, Washington, DC, USA
Venigalla B. Rao: ORCiD; Bacteriophage Medical Research Center, Department of Biology, The Catholic University of America, Washington, DC, USA

DOI: https://doi.org/10.1128/mBio.01361-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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Bacteriophages (phages) are viruses that infect bacteria and use them as replication factories to assemble progeny phages. Bacteria have evolved powerful defense mechanisms to destroy the invading phages by severing their genomes soon after entry into cells.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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