mBio
(Jun 2021)
Bacteriophage T4 Escapes CRISPR Attack by Minihomology Recombination and Repair
Xiaorong Wu,
Jingen Zhu,
Pan Tao,
Venigalla B. Rao
Affiliations
Xiaorong Wu
Bacteriophage Medical Research Center, Department of Biology, The Catholic University of America, Washington, DC, USA
Jingen Zhu
Bacteriophage Medical Research Center, Department of Biology, The Catholic University of America, Washington, DC, USA
Pan Tao
ORCiD Bacteriophage Medical Research Center, Department of Biology, The Catholic University of America, Washington, DC, USA
Venigalla B. Rao
ORCiD Bacteriophage Medical Research Center, Department of Biology, The Catholic University of America, Washington, DC, USA
DOI
https://doi.org/10.1128/mBio.01361-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Bacteriophages (phages) are viruses that infect bacteria and use them as replication factories to assemble progeny phages. Bacteria have evolved powerful defense mechanisms to destroy the invading phages by severing their genomes soon after entry into cells.
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