Myosin 7 and its adaptors link cadherins to actin

I-Mei Yu; Vicente J. Planelles-Herrero; Yannick Sourigues; Dihia Moussaoui; Helena Sirkia; Carlos Kikuti; David Stroebel; Margaret A. Titus; Anne Houdusse

doi:10.1038/ncomms15864

Nature Communications (Jun 2017)

Affiliations

I-Mei Yu: Structural Motility, Institut Curie, PSL Research University, CNRS, UMR 144
Vicente J. Planelles-Herrero: Structural Motility, Institut Curie, PSL Research University, CNRS, UMR 144
Yannick Sourigues: Structural Motility, Institut Curie, PSL Research University, CNRS, UMR 144
Dihia Moussaoui: Structural Motility, Institut Curie, PSL Research University, CNRS, UMR 144
Helena Sirkia: Structural Motility, Institut Curie, PSL Research University, CNRS, UMR 144
Carlos Kikuti: Structural Motility, Institut Curie, PSL Research University, CNRS, UMR 144
David Stroebel: Ecole Normale Supérieure, PSL Research University, CNRS, INSERM, Institut de Biologie de l'École Normale Supérieure (IBENS)
Margaret A. Titus: Department of Genetics, Cell Biology, and Development, University of Minnesota
Anne Houdusse: Structural Motility, Institut Curie, PSL Research University, CNRS, UMR 144

DOI: https://doi.org/10.1038/ncomms15864
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Cadherin is essential for mechanotransduction and myosin-adaptor-harmonin complexes anchor it to actin. Here the authors present the structures of myosin 7 MF2 domains bound to the harmonin PDZ3c domain and give insights into myosin-adaptor-harmonin complex assembly.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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