Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium

Bethany A. Kerr; Xiaoxia Z. West; Young-Woong Kim; Yongzhong Zhao; Miroslava Tischenko; Rebecca M. Cull; Timothy W. Phares; Xiao-Ding Peng; Jeremiah Bernier-Latmani; Tatiana V. Petrova; Ralf H. Adams; Nissim Hay; Sathyamangla V. Naga Prasad; Tatiana V. Byzova

doi:10.1038/ncomms10960

Nature Communications (Mar 2016)

Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium

Bethany A. Kerr,
Xiaoxia Z. West,
Young-Woong Kim,
Yongzhong Zhao,
Miroslava Tischenko,
Rebecca M. Cull,
Timothy W. Phares,
Xiao-Ding Peng,
Jeremiah Bernier-Latmani,
Tatiana V. Petrova,
Ralf H. Adams,
Nissim Hay,
Sathyamangla V. Naga Prasad,
Tatiana V. Byzova

Affiliations

Bethany A. Kerr: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic
Xiaoxia Z. West: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic
Young-Woong Kim: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic
Yongzhong Zhao: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic
Miroslava Tischenko: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic
Rebecca M. Cull: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic
Timothy W. Phares: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic
Xiao-Ding Peng: Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine at Chicago
Jeremiah Bernier-Latmani: Department of Fundamental Oncology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne
Tatiana V. Petrova: Department of Fundamental Oncology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne
Ralf H. Adams: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine
Nissim Hay: Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine at Chicago
Sathyamangla V. Naga Prasad: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic
Tatiana V. Byzova: Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic

DOI: https://doi.org/10.1038/ncomms10960
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 18

Abstract

Read online

The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and impaired Notch signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal