Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis

Priscila Ramos-Ibeas; Fei Sang; Qifan Zhu; Walfred W. C. Tang; Sarah Withey; Doris Klisch; Liam Wood; Matt Loose; M. Azim Surani; Ramiro Alberio

doi:10.1038/s41467-019-08387-8

Nature Communications (Jan 2019)

Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis

Priscila Ramos-Ibeas,
Fei Sang,
Qifan Zhu,
Walfred W. C. Tang,
Sarah Withey,
Doris Klisch,
Liam Wood,
Matt Loose,
M. Azim Surani,
Ramiro Alberio

Affiliations

Priscila Ramos-Ibeas: School of Biosciences, University of Nottingham
Fei Sang: School of Life Sciences, University of Nottingham
Qifan Zhu: School of Biosciences, University of Nottingham
Walfred W. C. Tang: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Sarah Withey: School of Biosciences, University of Nottingham
Doris Klisch: School of Biosciences, University of Nottingham
Liam Wood: School of Biosciences, University of Nottingham
Matt Loose: School of Life Sciences, University of Nottingham
M. Azim Surani: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Ramiro Alberio: School of Biosciences, University of Nottingham

DOI: https://doi.org/10.1038/s41467-019-08387-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

Read online

Lineage segregation from conception to gastrulation has been mapped at the single cell level in mouse, human and monkey. Here, the authors provide a comprehensive analysis of porcine preimplantation development using single cell RNA-seq; mapping metabolic changes, X chromosome inactivation and signalling pathways.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal