PLoS ONE (Jan 2014)

Temporary treatment during primary HIV infection does not affect virologic response to subsequent long-term treatment.

  • Marlous L Grijsen,
  • Ferdinand W N M Wit,
  • Suzanne Jurriaans,
  • Frank P Kroon,
  • Emile F Schippers,
  • Peter Koopmans,
  • Luuk Gras,
  • Joep M A Lange,
  • Jan M Prins,
  • Primo-SHM Study Group

DOI
https://doi.org/10.1371/journal.pone.0089639
Journal volume & issue
Vol. 9, no. 4
p. e89639

Abstract

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Temporary cART during primary HIV-infection (PHI) did not select for drug resistance mutations after treatment interruption and did not affect the subsequent virological response to long-term cART. Our data demonstrate that fear of drug resistance development is not a valid argument to refrain from temporary early treatment during PHI.