Insights into the antimicrobial effects of ceritinib against Staphylococcus aureus in vitro and in vivo by cell membrane disruption

Shasha Liu; Pengfei She; Zehao Li; Yimin Li; Yifan Yang; Linhui Li; Linying Zhou; Yong Wu

doi:10.1186/s13568-022-01492-w

AMB Express (Nov 2022)

Insights into the antimicrobial effects of ceritinib against Staphylococcus aureus in vitro and in vivo by cell membrane disruption

Shasha Liu,
Pengfei She,
Zehao Li,
Yimin Li,
Yifan Yang,
Linhui Li,
Linying Zhou,
Yong Wu

Affiliations

Shasha Liu: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Pengfei She: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Zehao Li: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Yimin Li: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Yifan Yang: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Linhui Li: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Linying Zhou: Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University
Yong Wu: Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University

DOI: https://doi.org/10.1186/s13568-022-01492-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Key points Ceritinib showed fierce lethality to the planktonic and persistent S. aureus. Ceritinib were highly effective in MRSA biofilm eradication and inhibition. The bactericidal mechanisms of ceritinib were showed by membrane breaking and ROS activation.

Published in AMB Express

ISSN: 2191-0855 (Online)
Publisher: SpringerOpen
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Microbiology
Website: http://www.amb-express.com/

About the journal

Abstract

Keywords