AMB Express
(Nov 2022)
Insights into the antimicrobial effects of ceritinib against Staphylococcus aureus in vitro and in vivo by cell membrane disruption
Shasha Liu,
Pengfei She,
Zehao Li,
Yimin Li,
Yifan Yang,
Linhui Li,
Linying Zhou,
Yong Wu
Affiliations
Shasha Liu
Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Pengfei She
Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Zehao Li
Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Yimin Li
Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Yifan Yang
Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Linhui Li
Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Linying Zhou
Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University
Yong Wu
Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University
DOI
https://doi.org/10.1186/s13568-022-01492-w
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Key points Ceritinib showed fierce lethality to the planktonic and persistent S. aureus. Ceritinib were highly effective in MRSA biofilm eradication and inhibition. The bactericidal mechanisms of ceritinib were showed by membrane breaking and ROS activation.
Keywords
Published in AMB Express
ISSN
2191-0855 (Online)
Publisher
SpringerOpen
Country of publisher
United Kingdom
LCC subjects
Technology: Chemical technology: Biotechnology
Science: Microbiology
Website
http://www.amb-express.com/
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