In-vitro engineered human cerebral tissues mimic pathological circuit disturbances in 3D

Aref Saberi; Albert P. Aldenkamp; Nicholas A. Kurniawan; Carlijn V. C. Bouten

doi:10.1038/s42003-022-03203-4

Communications Biology (Mar 2022)

In-vitro engineered human cerebral tissues mimic pathological circuit disturbances in 3D

Aref Saberi,
Albert P. Aldenkamp,
Nicholas A. Kurniawan,
Carlijn V. C. Bouten

Affiliations

Aref Saberi: Department of Biomedical Engineering, Eindhoven University of Technology
Albert P. Aldenkamp: School for Mental Health and Neuroscience, Maastricht University Medical Center
Nicholas A. Kurniawan: Department of Biomedical Engineering, Eindhoven University of Technology
Carlijn V. C. Bouten: Department of Biomedical Engineering, Eindhoven University of Technology

DOI: https://doi.org/10.1038/s42003-022-03203-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 9

Abstract

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A method is developed to engineer cerebral tissues with intact 3D neuronal networks, mimicking neuropathological signatures such as the propagation of epileptiform discharges, using a multi-chambered tissue culture chip.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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