Nature Communications (Feb 2021)
Dynamic sex chromosome expression in Drosophila male germ cells
- Sharvani Mahadevaraju,
- Justin M. Fear,
- Miriam Akeju,
- Brian J. Galletta,
- Mara M. L. S. Pinheiro,
- Camila C. Avelino,
- Diogo C. Cabral-de-Mello,
- Katie Conlon,
- Stafania Dell’Orso,
- Zelalem Demere,
- Kush Mansuria,
- Carolina A. Mendonça,
- Octavio M. Palacios-Gimenez,
- Eli Ross,
- Max Savery,
- Kevin Yu,
- Harold E. Smith,
- Vittorio Sartorelli,
- Haiwang Yang,
- Nasser M. Rusan,
- Maria D. Vibranovski,
- Erika Matunis,
- Brian Oliver
Affiliations
- Sharvani Mahadevaraju
- Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Kidney and Digestive Diseases, National Institutes of Health
- Justin M. Fear
- Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Kidney and Digestive Diseases, National Institutes of Health
- Miriam Akeju
- Department of Cell Biology, Johns Hopkins University School of Medicine
- Brian J. Galletta
- Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health
- Mara M. L. S. Pinheiro
- Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo
- Camila C. Avelino
- Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo
- Diogo C. Cabral-de-Mello
- Instituto de Biociências/IB, Departamento de Biologia Geral e Aplicada, UNESP—Universidade Estadual Paulista, Rio Claro
- Katie Conlon
- Department of Cell Biology, Johns Hopkins University School of Medicine
- Stafania Dell’Orso
- Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
- Zelalem Demere
- Department of Cell Biology, Johns Hopkins University School of Medicine
- Kush Mansuria
- Department of Cell Biology, Johns Hopkins University School of Medicine
- Carolina A. Mendonça
- Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo
- Octavio M. Palacios-Gimenez
- Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo
- Eli Ross
- Department of Cell Biology, Johns Hopkins University School of Medicine
- Max Savery
- Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Kidney and Digestive Diseases, National Institutes of Health
- Kevin Yu
- Department of Cell Biology, Johns Hopkins University School of Medicine
- Harold E. Smith
- Genomics Core, National Institute of Diabetes and Kidney and Digestive Diseases, National Institutes of Health
- Vittorio Sartorelli
- Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
- Haiwang Yang
- Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Kidney and Digestive Diseases, National Institutes of Health
- Nasser M. Rusan
- Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health
- Maria D. Vibranovski
- Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo
- Erika Matunis
- Department of Cell Biology, Johns Hopkins University School of Medicine
- Brian Oliver
- Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Kidney and Digestive Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-021-20897-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Sex chromosome gene content and expression is unusual. Here the authors use single cell RNA-Seq on Drosophila larvae to demonstrate that the single X and pair of 4th chromosomes are specifically inactivated in primary spermatocytes, while genes on the single Y chromosome become maximally active in primary spermatocytes.
