Nature Communications (Mar 2019)

The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins

  • Bernat Blasco-Moreno,
  • Leire de Campos-Mata,
  • René Böttcher,
  • José García-Martínez,
  • Jennifer Jungfleisch,
  • Danny D. Nedialkova,
  • Shiladitya Chattopadhyay,
  • María-Eugenia Gas,
  • Baldomero Oliva,
  • José E. Pérez-Ortín,
  • Sebastian A. Leidel,
  • Mordechai Choder,
  • Juana Díez

DOI
https://doi.org/10.1038/s41467-019-09199-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

The exonuclease Xrn1 mediates crosstalk between transcription and mRNA decay in yeast. Here the authors demonstrate that Xrn1 promotes translation of mRNAs encoding membrane proteins, coupling transcription, translation, and mRNA decay.