Recent advances in understanding and managing psoriatic arthritis [version 1; referees: 2 approved]

Abstract

This article reviews recent advances in psoriatic arthritis (PsA) over the past several years with emphasis on early diagnosis, better understanding of pathogenesis, and new therapeutic approaches. Early diagnosis is important, since people who present late do not fare as well. There are a number of clinical, laboratory, and ultrasound features that can help identify patients destined to develop PsA, and several screening tools have been developed. It is recognized that genetic and epigenetic factors, as well as T cells and cytokines, play a role in the pathogenesis of PsA, and several targets have been identified for therapeutic interventions. New therapies have been developed and tested in PsA and have been found to be highly effective for both skin and joint manifestations of the disease. The expectation is that, in the future, PsA patients will be treated early and more aggressively and that there will not be significant progression of joint damage. Moreover, with effective treatment of the skin and joint disease and management of risk factors for the comorbidities, we can expect to reduce their occurrence and further reduce the excess mortality and reduced quality of life and function in these patients.

Keywords

• Dermatologic Pharmacology
• Genetics of the Immune System
• Immune & Inflammatory Rheumatic Diseases (incl. Arthritis)
• Immunopharmacology & Hematologic Pharmacology
• Innate Immunity
• Medical Genetics
• Musculoskeletal Pharmacology
• Psoriasis & Other Inflammatory Diseases