Communications Biology (Aug 2022)
MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine
Abstract
Analogs of methyl-oxalylglycine (MOG) were generated as tools to study the monocarboxylate transporter MCT2, an understudied SLC16 family member. These compounds still inhibit prolyl hydroxylases but have minimal metabolic and cytotoxic effects.