mBio (Apr 2021)

Cryo-Electron Tomography of the Herpesvirus Procapsid Reveals Interactions of the Portal with the Scaffold and a Shift on Maturation

  • Michael H. C. Buch,
  • William W. Newcomb,
  • Dennis C. Winkler,
  • Alasdair C. Steven,
  • J. Bernard Heymann

DOI
https://doi.org/10.1128/mBio.03575-20
Journal volume & issue
Vol. 12, no. 2

Abstract

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Herpes simplex virus 1 (HSV-1) infects a majority of humans, causing mostly mild disease but in some cases progressing toward life-threatening encephalitis. Understanding the life cycle of the virus is important to devise countermeasures.