Influence of indicators for thiotriazolin phagocytic activity of leukocytes in the blood in the later period of development of stomach ulcers against pneumonia

Abstract

Important for the pathogenesis of pneumonia and gastric ulcers should state phagocytic activity of leukocytes (PHAL) in the blood. In fact the state of nonspecific resistance factors to some extent depends on the disease, the development of complications, prognosis and therapy. Materials and methods. The study was conducted on 49 male guinea pigs. The experimental pneumonia caused by the method Shlyapnykova V. N., Solodova T. L., gastric ulcer simulated method Komarov V. I. Nonspecific resistance of animals we evaluated, examining the phagocytic activity of leukocytes (PHAL), nitroblue tetrazolium test (NST- test). Phagocytic activity of leukocytes (PHAL) in blood were studied in terms phagocytic index (PHI) and the phagocytic number (PHN) and determined by the method Menshikov V. V. NST - test method Vyksmana M. E., Mayanskoho A. H. The figures research results processed by statistical method Student. Results and discussion. For the experiment, we selected two models of disease: experimental pneumonia (EP) and peptic ulcer (PU). State PHAL determined by the level of phagocytic number (PHN), phagocytic index (PHI), NST-test levels in the ЕP+ PU. Found that in the 10-th and 18-th day of development of pathological process both in the stomach and the lungs of guinea pigs, there was reduction of PHI respectively 15,8% (P

Keywords

• pneumonia
• peptic ulcer.