Nature Communications (Feb 2017)

p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation

  • Ashwini Hinge,
  • Juying Xu,
  • Jose Javier,
  • Eucabeth Mose,
  • Sachin Kumar,
  • Reuben Kapur,
  • Edward F. Srour,
  • Punam Malik,
  • Bruce J. Aronow,
  • Marie-Dominique Filippi

DOI
https://doi.org/10.1038/ncomms14382
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

The success of hematopoietic stem cell (HSC) transplantation relies on understanding what regulates the fate decision to self-renew. Here, the authors show using bothin vitro assays and in vivotransplantation that loss of the RhoGAP p190-B enhances self-renewal by inhibiting TGFβ/p38 signalling.